Saturday, November 19, 2005
Center of Excellence Proposal
à
Professor
Lander
Professor
of Biology, MIT
Professor
of Systems Biology, Harvard Medical
School
Founding
Director, The Broad Institute of MIT
and Harvard
With
respects and appreciation for your time.
My name is
Dr Paul Prueitt (PhD in mathematics).
Might you
provide some reading from your lab that would support a generalization of the
notion developed by Gerald Edelman, of a response degeneracy in neuronal
ensemble expression? I need a list of
the best scholarship on this issue but unfortunately mathematical degeneracy (a
saddle point) is what goggle brings back, mostly.
And there
is deep controversy over this notion of stratification of ontology (reality) in
spite the evidences from quantum theory ...
I am
working to try to impress on computer scientists that a many to many mapping
between substructural assemble and functional expression is the rule in
biology. If this point can be made,
then the way is open to setting aside (what some feel are) errors being made in
the Semantic Web (W3C) standards for web services supporting biology research,
etc.
My work
is way outside the mainstream computer science discipline, and yet I still feel
that my work will be seen in the future as acceptable:
http://www.bcngroup.org/area3/pprueitt/book.htm
Being now
54, this may not happen in my life time.
But I am hopeful.
I want to
develop an argument to be made to some of the ontology standards groups (GSA,
NSF, DARPA) that response degeneracy is necessary to any formal modeling of
process. I want to use biological
science, and ground my argument in the best work available on this issue.
Part of
the discussion I am having is recorded in a web log (of my own design) at:
http://www.ontologystream.com/beads/nationalDebate/208.htm
It is
obvious to me, that those involved in computer science and "ontology"
are not aware of the empirical bases for asserting ubiquitous
function/structure degeneracy.
http://www.ontologystream.com/aSLIP/files/stratification.htm
Perhaps
you will help me, and thus "them".